What is CK7 positive in breast cancer?
CK7 and GATA3 staining was considered positive if 1% or more of tumor cells were stained with at least mild intensity.
What is CK7 positive in cancer?
For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.
What is ImmunoHistoChemistry breast cancer?
IHC, or ImmunoHistoChemistry, is a special staining process performed on fresh or frozen breast cancer tissue removed during biopsy. IHC is used to show whether or not the cancer cells have HER2 receptors and/or hormone receptors on their surface. This information plays a critical role in treatment planning.
What is the commonest type of breast cancer by immunohistochemical classification?
Invasive ductal carcinoma (IDC) is the most common form of invasive breast cancer. It accounts for 55% of breast cancer incidence upon diagnosis.
What is E cadherin positive?
A negative E-cadherin stain was a sensitive and specific biomarker to confirm the diagnosis of invasive lobular carcinoma (specificity 97.7%; negative predictive value 96.8%; sensitivity 88.1%; and positive predictive value 91.2%). Positive E-cadherin expression was also associated with tubulolobular carcinomas.
Can squamous cell carcinoma be CK7 positive?
Positivity for any neuroendocrine marker was seen in 5 (8%) cases of squamous cell carcinoma and 14 (12%) cases of adenocarcinoma (of which 3 cases were positive in 2 markers). Squamous cell carcinoma positive for cytokeratin 7 (CK7).
What is Napsin a positive?
Napsin A and thyroid transcription factor-1 (TTF-1) are known to be useful immunohistochemical markers to distinguish primary lung cancers from metastatic lung tumors. These markers are usually positive in primary lung adenocarcinomas but not metastatic adenocarcinomas in other organs.
What does HER2-negative mean in breast cancer?
When a breast cancer is HER2-negative, it means that the cancerous cells do not contain high levels of the protein HER2. There are many treatment options available for this type of breast cancer, but the prognosis can vary.
What is the survival rate of invasive ductal carcinoma breast cancer?
Invasive ductal carcinoma describes the type of tumor in about 80 percent of people with breast cancer. The five-year survival rate is quite high — almost 100 percent when the tumor is caught and treated early.
What is ductal cancer?
Ductal carcinoma in situ (DCIS) means the cells that line the milk ducts of the breast have become cancer, but they have not spread into surrounding breast tissue. DCIS is considered non-invasive or pre-invasive breast cancer.
What does immunohistochemical staining show for CK7?
Comment: Immunohistochemical staining demonstrates diffuse tumor positivity for CK7, GATA3, ER and PR and negativity for CK20, TTF-1, WT-1 and Pax-8. The morphologic and immunophenotypic findings are consistent with metastatic breast adenocarcinoma.
What kind of cancer can CK7 be used for?
Squamous cell carcinoma (with exception of cervix, a subset of head and neck squamous cell carcinomas and a subset of cutaneous squamous cell carcinomas, particularly poorly differentiated tumors, which can express focal-to-partial positivity for CK7) ( Head Neck Pathol 2018;12:448, J Cutan Pathol 2010;37:966 )
Which is more specific CK7 or CD117?
Addition of Claudin-7 and CD117 to CK7 or the “three 7 markers” further increases specificity for chromophobe renal cell carcinoma versus other histologic mimics ( Dis Markers 2019;2019:4708154 )
Can a CK7 tumor be differentiated from a SATB2 tumor?
Primary ovarian mucinous tumors can be differentiated from lower gastrointestinal primaries by utilizing a two marker combination of CK7 and SATB2 with greater than 95% accuracy (in many cases primary ovarian mucinous tumors are CK7+, SATB2-) ( Modern Pathol 2019;32:1834 )
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