Can dendritic cells undergo phagocytosis?
Like macrophages and neutrophils, dendritic cells (DCs) are considered professional phagocytes. Even if the three cell types phagocytose parasites, bacteria, cell debris, or even intact cells very efficiently, the functional outcomes of the phagocytic event are quite different.
What is CD11c a marker for?
CD11c is abundantly expressed in monocytes and macrophages. Paraffin reactive antibodies have been developed for this antigen and can certainly be used to give evidence for a histiocytic origin for lesion but make an excellent marker for hairy cell leukemia in paraffin-embedded tissue.
Do dendritic cells express CD11c?
CD11c, a commonly used dendritic cell (DC) marker, is expressed by other immune cells as well, such as T cells. This study analyzed the immune cells that express CD11c and monitored the expression level of their specific cell surface markers in the lung following a disseminated murine (M)CMV infection.
Are immature dendritic cells phagocytic?
Phagocytosis is one of the basic properties of immature DCs in the innate immunity. In the immature state, DCs detect and take up pathogens, which they digest and process to express the antigenic information on their surfaces, coupled to MHC molecules.
Which cells can phagocytosis?
However, only a specialized group of cells called professional phagocytes (1) accomplish phagocytosis with high efficiency. Macrophages, neutrophils, monocytes, dendritic cells, and osteoclasts are among these dedicated cells.
Do macrophages express CD11c?
It is now recognized that several non-DC myeloid populations express CD11c, including alveolar macrophages and resident (Ly6C low) monocytes and that some macrophage populations express both CD11c and MHC class II [8, 9]. Similarly, CD11b has often been used as a marker for all myeloid cell types.
Are dendritic cells CD14+?
CD14+ dendritic cells These cells were originally identified as migrant CD14+ populations from human skin. They were previously referred to as ‘interstitial-type’ or ‘dermal-type’ DCs (to contrast with epidermal LCs) but this term is misleading because it ignores the major population of CD1c+ interstitial mDCs.
What is the main function of a dendritic cell?
Dendritic cells (DCs) represent a heterogeneous family of immune cells that link innate and adaptive immunity. The main function of these innate cells is to capture, process, and present antigens to adaptive immune cells and mediate their polarization into effector cells (1).
What does CD11c stand for in immunohistology?
Immunohistology of Non-Hodgkin Lymphoma. CD11C. CD11c is a type I transmembrane protein that is expressed on monocytes, granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia.
How is integrin CD11c used in dendritic cells?
The positive recognition system used by dendritic cells to capture CD47-deficient cells has been unknown. Here we show that the integrin CD11c, a classical marker of dendritic cells, and cytoskeletal protein talin are critically involved in binding and uptake of missing-self CD47 cells.
How does CD11c work in the bone marrow?
CD11c + LT DC development in the bone marrow requires expression by DC precursors of Flt3, a cytokine receptor, and its binding of FMS-related tyrosine kinase 3 (Flt3)-ligand, which is produced by nonhematopoietic stromal cells. 41
How does cd11c-cre affect CD1s and cdc2s?
CD11c-Cre caused efficient depletion of Talin protein in both cDC1s and cDC2s, whereas Talin expression in other cells was either less affected (plasmacytoid DCs) or unaffected (B cells) ( SI Appendix, Fig. S2 A ). Talin1-deficient DCIR2 + DCs were strongly compromised in their ability to capture Cd47−/− RBCs, thymocytes, and BM cells ( Fig. 1 A ).