Should Gleason 3/4 Be Treated?

Current American Society of Clinical Oncology (ASCO)/Cancer Care Ontario (CCO) guidelines recommend treatment for most men with intermediate-risk disease, but state that men with low-volume Gleason 3+4 prostate cancer may be considered for active surveillance.

What stage cancer is Gleason 3 4?

Stages of prostate cancer

AJCC Stage Stage grouping
IIB T1 or T2, N0, M0 Grade Group 2 (Gleason score 3+4=7) PSA less than 20
IIC T1 or T2, N0, M0 Grade Group 3 or 4 (Gleason score 4+3=7 or 8) PSA less than 20
IIIA T1 or T2, N0, M0 Grade Group 1 to 4 (Gleason score 8 or less) PSA at least 20

Is a Gleason score of 4 Bad?

This distinction indicates how aggressive the tumor is. Scores of 3 + 4 typically have a good outlook. A score of 4 + 3 is more likely to grow and spread than the 3 + 4 score, but less likely to grow and spread than a score of 8. Some people receive multiple Gleason scores.

What does a Gleason score of 3 3 6 mean?

If a tumor is all the same grade (for example, grade 3), then the Gleason score is reported as 3+3=6.

What is the life expectancy with a Gleason score of 6?

In a competing risk analysis of 767 men aged 55 to 74 years who were managed conservatively for localized disease, Albertsen and colleagues (4) found that men with Gleason score 5 or 6 tumors had a modest risk of death from prostate cancer, ranging from 6% to 30%, over 15 years of follow-up.

Does Gleason 6 need treatment?

Since the Gleason 6 lacks the hallmarks of a cancer, it is a pseudocancer, not a health risk; does not progress to become a health risk; needs no detection; and needs no treatment.

What does a Gleason score of 3 3 mean?

Gleason 3+3 is a hard six in prostate cancer. It is the lowest grade cancer in the traditional Gleason scoring system. Still, to the eye of a pathologist, a Gleason 6 looks like a malignancy.

Is Gleason 7 serious?

A Gleason score of 7 is a medium-grade cancer, and a score of 8, 9, or 10 is a high-grade cancer. A lower-grade cancer grows more slowly and is less likely to spread than a high-grade cancer.