What does SH3 domain do?
The SH3 domain of Src-family PTKs, which regulate many cellular functions, such as cell proliferation and differentiation, survival, migration and cytoskeletal modifications, is mainly involved in substrate recognition and downregulation of the kinase activity.
What do proteins with SH3 domains bind to?
SH3 domains bind to target proteins through sequences containing proline and hydrophobic amino acids.
What is a domain containing protein?
A protein domain is a region of the protein’s polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of several domains. One domain may appear in a variety of different proteins.
Is SH3 an acid?
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site.
Which intracellular proteins contain Sh2 domains?
The SH2 domain-containing phosphatases (Shps) belong to a class of non-transmembrane protein tyrosine phosphatases that contain two N-terminal SH2 domains. There are two vertebrate Shps: SHP1 and SHP2.
What is difference between Motif and domain?
A motif is a short conserved sequence pattern associated with distinct functions of a protein or DNA. It is often associated with a distinct structural site performing a particular function. A domain is also a conserved sequence pattern, defined as an independent functional and structural unit.
What are the subunits of protein?
In the case of proteins, those subunits are amino acids. Any amino acid features a central carbon atom that is connected to an amino group, a hydrogen atom, and a carboxyl group.
Does SOS have an SH2 domain?
The Son of Sevenless (Sos) proteins control receptor-mediated activation of Ras by catalyzing the exchange of guanosine diphosphate for guanosine triphosphate on Ras. The NH2-terminal region of Sos contains a Dbl homology (DH) domain in tandem with a pleckstrin homology (PH) domain.
What is WW in biology?
The WW domain, (also known as the rsp5-domain or WWP repeating motif) is a modular protein domain that mediates specific interactions with protein ligands. This domain is found in a number of unrelated signaling and structural proteins and may be repeated up to four times in some proteins.
What are modular domains?
Modular protein interacting domains facilitate protein-protein interactions required for a diverse set of cellular processes including signal transduction and subcellular localization. The combination of modular domains within a protein contributes to its biological function by defining its protein interaction network.
Where are SH3 domains found in the cell?
SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site.
How does SH3 interact with adaptor and tyrosine kinases?
The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site.
Are there any binding motifs in the SH3 domain?
Other SH3 binding motifs have emerged and are still emerging in the course of various molecular studies, highlighting the versatility of this domain.
How many amino acids are in the Src homology 3 domain?
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues.