What is CD11b a marker for?
. CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection.
What cells are CD11b+?
CD11b is expressed on the surface of many leukocytes including monocytes, neutrophils, natural killer cells, granulocytes and macrophages, as well as on 8% of spleen cells and 44% of bone marrow cells.
Are macrophages CD11b+?
CD11 is involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. …
Do endothelial cells express CD11b?
In this study, we have identified the human Thy-1 (CD90) ex- pressed on activated endothelial cells as a new counterreceptor for the leukocyte ß2 integrin Mac-1 (αMß2; CD11b/CD18). Recently, the human Thy-1 could be identified as an activation- associated cell adhesion molecule on HDMEC (29, 30).
Do all macrophages express CD11b?
It is now recognized that several non-DC myeloid populations express CD11c, including alveolar macrophages and resident (Ly6C low) monocytes and that some macrophage populations express both CD11c and MHC class II [8, 9]. Similarly, CD11b has often been used as a marker for all myeloid cell types.
Do lymphocytes express CD11b?
CD11b (Leu15) epitope is expressed on 20-30% of peripheral blood lymphocytes, including CD16+ large granular lymphocytes and CD8+ cells.
Do T cells express CD11c?
CD11c is an α integrin classically employed to define myeloid dendritic cells. Although there is little information about CD11c expression on human T cells, mouse models have shown an association of CD11c expression with functionally relevant T cell subsets.
Do T cells express Ly6C?
Ly6C is a murine cell-surface antigen expressed by plasma cells, subsets of myeloid cells and many T cells, including memory T cells.
Do human macrophages express CD11c?
Although monocytes, macrophages and dendritic cells are thought to express CD11b and CD11c in similarly high amounts, precise numbers assessed by us show significant differences.
What happens to hepatic F4 / 80 + CD11b + cells?
Isolated hepatic MNCs and F4/80 + CD11b + cells of LXRα/β-KO mice showed enhanced production of inflammatory cytokines after stimulation by lipopolysaccharide or CpG-DNA compared to WT cells, and LXR ligand treatment suppressed lipopolysaccharide-induced cytokine expression in hepatic MNCs.
Are there any F4 / 80 positive Kupffer cells?
Two F4/80(+) Kupffer cell subsets may exist, a CD68(+) subset with phagocytic activity and a CD11b(+) subset with cytokine-producing capacity. Two F4/80(+) Kupffer cell subsets may exist, a CD68(+) subset with phagocytic activity and a CD11b(+) subset with cytokine-producing capacity.
What is the expression of F4 / 80 in hepatic MNCs?
Expression of common macrophage marker genes, F4/80 (gene symbol, Adgre1), CD11b (Itgam) and CD68 (Cd68), was significantly elevated in hepatic MNCs of LXRα/β-KO mice (Fig. 5a). Macrophages are divided into two types, proinflammatory M1 macrophages and anti-inflammatory M2 macrophages 24.
Are there any other cells that express F4 / 80?
Popular Answers ( 2) Now take into account that there are other cell in the tissues: neutrophils, DCs, eosinophils, mast cells – they can overlap with macrophages and obscure them. Monocytes are F4/80low and most of the monocyte-derived macrophages are F4/80low. Eosinophils express F4/80 as well (though less than macrophages).