What is the meaning of bursa of Fabricius?

: a lymphoid organ that opens into the cloaca of birds and functions in B cell production.

What is the function of Bursa Fabricius?

The bursa of Fabricius is a primary lymphoid organ of birds. Its main function is hematopoiesis and development of B lymphocytes. It is located dorsal to the proctodic region of the cloaca and has the form of a small bag. The surface of bursa is constituted by folds that give it the appearance of book sheets.

Is bursa of Fabricius primary lymphoid organ?

The bursa of Fabricius is a primary and secondary lymphoid organ considered exclusively present in birds, and studies of this structure have been vital to our current understanding of the adaptive immune system of vertebrates.

What happens if bursa of Fabricius is removed?

Surgical removal of the bursa of Fabricius from newly hatched chicks resulted in a depletion of immunoglobulin A (IgA) from serum and bile of 55 and 67% of the birds, respectively, up to 11 weeks of age.

What is bursa equivalent?

bursa-equivalent tissue (bursal equivalent tissue) a hypothesized lymphoid tissue in nonavian vertebrates including human beings, equivalent to the bursa of Fabricius in birds: the site of B lymphocyte maturation. It now appears that B lymphocyte maturation occurs primarily in the bone marrow.

What does cloaca mean in English?

1 : sewer entry 3. 2a [New Latin, from Latin] : the common chamber into which the intestinal and urogenital tracts discharge especially in monotreme mammals, birds, reptiles, amphibians, and elasmobranch fishes also : a comparable chamber of an invertebrate.

Is bursa of Fabricius present in human?

An organ in the cloacal-hind gut junction birds found to be important in the maturation of B lymphocytes (B for bursa). The equivalent in humans is probably the tonsils or lymphoid tissue in the intestine.

What is bursa in bird?

The bursa of Fabricius, a lymphoid organ found only in birds, is an important tissue for B cell maturation [1,42]. The internal surface of the bursa of Fabricius contains many folds and large numbers of lymphoid follicles. This surface is covered with specialized epithelial cells that can take up luminal Ags.

Do all birds have a bursa of Fabricius?

The bursa is an epithelial and lymphoid organ that is found only in birds. The bursa develops as a dorsal diverticulum of the proctadael region of the cloaca.

What does the bursa of Fabricius stand for?

Bursa of Fabricius. Jump to navigation Jump to search. In birds, the bursa of Fabricius (Latin: Bursa cloacalis or Bursa fabricii) is the site of hematopoiesis, a specialized organ that, as first demonstrated by Bruce Glick and later by Max Cooper and Robert Good, is necessary for B cell (part of the immune system) development in birds.

Why are B lymphocytes called the bursa of Fabricius?

The bursa was the first place that a certain subset of lymphocytes was observed and consequently they were named B lymphocytes (bursa of Fabricius or bursa equivalent organs). The bursa is involved in the differentiation of B lymphocytes.

Is the bursa a primary lymphoid organ in birds?

It is a primary lymphoid organ found in birds. The bursa was the first place that a certain subset of lymphocytes was observed and consequently they were named B lymphocytes ( b ursa of Fabricius or b ursa equivalent organs). The bursa is involved in the differentiation of B lymphocytes.

How many plicae are there in the Bursa?

The bursa develops as a dorsal diverticulum of the proctadael region of the cloaca. The luminal (interior) surface of the bursa is plicated with as many as 15 primary and 7 secondary plicae or folds. These plicae have hundreds of bursal follicles containing follicle-associated epithelial cells, lymphocytes, macrophages, and plasma cells.