What is the purpose of the cilastatin?

Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia), urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections.

What is the function of imipenem and cilastatin?

Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs.

How does Relebactam work with imipenem cilastatin to fight against multidrug resistance gram negative infections?

In vitro, the addition of relebactam significantly improves the antibacterial activity of imipenem by lowering the minimum inhibitory concentration (MIC) of imipenem by 2- to 128-fold against ESBL- or KPC-producing Enterobacterales, as well as MDR or imipenem-resistant Pseudomonas aeruginosa isolates [2, 10, 16–20].

Is cilastatin a beta lactamase inhibitor?

Imipenem-cilastatin-relebactam (IMI-REL) is a novel β-lactam-β-lactamase inhibitor combination recently approved for the treatment of complicated urinary tract infections (cUTIs) and complicated intraabdominal infections (cIAIs).

What bacteria does imipenem cover?

Imipenem is active against aerobic and anaerobic Gram positive as well as Gram negative bacteria including Pseudomonas aeruginosa and the Enterococcus.

What is primaxin used to treat?

This medication is used to treat a wide variety of bacterial infections. This medication is known as a carbapenem-type antibiotic. It works by stopping the growth of bacteria.

What is the action of imipenem?

Imipenem + cilastatin is a beta-lactam antibiotic of the carbapenems class with a broad spectrum of activity. The mechanism of action is similar to the other beta-lactam antibiotics, which is to inactivate the penicillin-binding proteins (PBP) and cause cell wall lysis, or interfere with cell wall formation.

Is Recarbrio expensive?

The cost for Recarbrio intravenous powder for injection 1.25 g is around $7,201 for a supply of 25 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

How does relebactam work?

Relebactam is in a class of medications called beta-lactamase inhibitors. It works by preventing bacteria from destroying imipenem. Antibiotics such as imipenem, cilastatin, and relebactam injection will not work for colds, flu, or other viral infections.

What are beta-lactamase inhibitors used for?

Beta-lactamase inhibitors are medications that are used ubiquitously in modern medicine due to their ability to combat bacterial antimicrobial resistance mechanisms. Antimicrobial resistance poses an enormous global public health challenge.

What antibiotics are beta-lactam and beta-lactamase inhibitors?

The activity of the beta-lactams: amoxicillin, ampicillin, piperacillin, and ticarcillin, can be restored and widened by combining them with a beta-lactamase inhibitor. Clavulanic acid, sulbactam, and tazobactam are all beta-lactamase inhibitors.

What bacteria does primaxin cover?

Imipenem has a broad spectrum of activity against aerobic and anaerobic, Gram-positive and Gram-negative bacteria. It is particularly important for its activity against Pseudomonas aeruginosa and the Enterococcus species.

What does cilastatin do to the human body?

Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect.

How does cilastatin protect against the degradation of imipenem?

Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from degradation, prolonging its antibacterial effect.

What kind of enzyme is cilastatin an inhibitor of?

Cilastatin is an inhibitor of renal dehydropeptidase, an enzyme responsible for both the metabolism of thienamycin beta-lactam antibiotics as well as conversion of leukotriene D4 to leukotriene E4.

What is the renal clearance of cilastatin?

Cilastatin has a total clearance of 0.2 L/h/kg and a renal clearance of 0.10-0.16 L/h/kg. The half-life of cilastatin is approximately 1h.