What is vimentin a marker for?
In recent years, vimentin has been recognized as a marker for epithelial-mesenchymal transition (EMT). Although EMT is associated with several tumorigenic events, vimentin’s role in the underlying events mediating these processes remains unknown.
What cells express vimentin?
Vimentin is a widely expressed and highly conserved 57-kD protein that is constitutively expressed in mesenchymal cells, including endothelial cells lining blood vessels, renal tubular cells, macrophages, neutrophils, fibroblasts, and leukocytes (3–8).
What is vimentin positive?
Vimentin staining confirms mesenchymal origin of some tumors; may be the only positive stain in certain cases and thus confirms that the tissue is capable of staining (Am J Surg Pathol 2011;35:1722)
Are macrophages vimentin positive?
Cell-surface vimentin-positive macrophage-like circulating tumor cells as a novel biomarker of metastatic gastrointestinal stromal tumors. Oncoimmunology.
Is vimentin a mesenchymal marker?
Vimentin is one type of EMT protein marker, which is present in mesenchymal cells and involved in cancer progression [4, 7, 11, 15].
Where is vimentin in the cell?
Vimentin IFs are found in the cytoplasm of mesenchymal cells, where it functions to maintain the cyto-architecture and tissue integrity (4). Vimentin is known to interact with a large number of proteins and participates in various cellular functions (few of the interactors are summarized in Table 1).
What does CD10 positive mean?
Conclusion: CD10 is a reliable and sensitive immunohistochemical marker of normal endometrial stroma. Positivity, which is often strong and/or diffuse is found in endometrial stromal nodules and low-grade ESS.
Is vimentin a fibroblast marker?
Fibroblast Marker (Vimentin, alpha smooth muscle Actin, Hsp47, S100A4) Antibody Panel – Human, Mouse ab254015 contains multiple trial-sized versions of anti-human and mouse antibody clones against Vimentin, alpha smooth muscle Actin, Hsp47, S100A4, specifically selected for high performance in various applications.
What does vimentin stain?
Vimentin stains virtually all spindle cell neoplasms—mesenchymal spindle cell neoplasms and sarcomatoid carcinomas included. However, vimentin stains a subset of carcinomas regularly and to a significant degree, and this may be useful in the context of a panel of antibodies to narrow a differential diagnosis.
Is cytokeratin and keratin same?
Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue. They are an important component of intermediate filaments, which help cells resist mechanical stress. Expression of these cytokeratins within epithelial cells is largely specific to particular organs or tissues.