Can proton pump inhibitors cause memory loss?

Memory impairment related ADRs found that PPIs users were at increased risk of dementia (Hazard Ratio (HR) 1.38, 95% CI, [1.04–1.83]) and AD (HR, 1.44, 95% CI, [1.01, 2.06]) compared to non-users19.

Do proton pump inhibitors increase the risk of dementia?

showed an increased dementia risk with PPIs use (HR 1.29; 95% CI 1.12–1.49). In subgroup analyses, a significant association was detected between PPI use and the risk of dementia in Europe (HR 1.46; 95% CI 1.23–1.73) and among participants aged ≥ 65 years (HR 1.39, 95% CI 1.17–1.65).

Is there a link between omeprazole and dementia?

The patients who had been regularly taking a PPI, such as omeprazole (Prilosec), pantoprazole (Protonix), lansoprazole (Prevacid), esomeprazole (Nexium) and rabeprazole (AcipHex), had a significantly increased risk of incident dementia compared with patients who did not take the medication.

Are PPIs linked to dementia?

A recent study have found that PPI use was also associated with an increased risk of incident dementia. Dementia is a chronic, progressive, multifactorial syndrome characterized by a decline in cognitive function and capacity for independent living.

Is PPI damage reversible?

Over 5 years of follow up, results indicate that more than 80% of PPI users did not develop acute kidney problems, which are usually reversible issues that create symptoms such as fatigue and swelling in the legs and ankles.

Can GERD cause memory loss?

Researchers say the memory problems were between 20% and 29% more severe than those reported by patients who didn’t use PPIs. Annelise Madison, a Ph. D.

What can I use instead of a PPI?

Alternatives to PPIs

  • Cimetidine (Tagamet)
  • Ranitidine (Zantac)
  • Nizatidine (Axid)
  • Famotidine (Pepcid)

What is considered long term use of PPIs?

The threshold for defining long-term PPI use varied from >2 weeks to >7 years of PPI use. The most common definition was ≥1 year (10 studies) or ≥6 months (10 studies). Nine studies defined long-term use as ≥8 weeks.

Does omeprazole affect the brain?

Both omeprazole and lansoprazole cross the blood-brain barrier, which means they could directly affect the brain. To test this suspicion, researchers at Emory University in Atlanta gathered data on 10,486 participants age 50 and up with either normal or slightly impaired cognitive function.

What happens when you stop taking PPIs?

Stopping PPI treatment can cause rebound acid hypersecretion, leading to the transient appearance of symptoms such as indigestion, heartburn or regurgitation.

Can GERD cause dementia?

Long-term use of popular acid reflux medications may increase dementia risk, say investigators. But careful short-term use in elders remains safe, they claim.

What are the dangers of proton pump inhibitors?

Studies have linked proton pump inhibitors to serious, sometimes life-threatening side effects. Higher dosages and long-term use increase the risk for many of those complications. Prolonged use of these medicines can cause kidney disease, injury and failure. It can also lead to heart attacks, cancers and bone fractures.

What is the most effective proton pump inhibitor?

Proton pump inhibitors such as Prilosec (omeprazole) and Nexium (esomeprazole) are among the most widely-prescribed medications on earth. Used for the treatment of gastroesophageal reflux disease (GERD), they are effective and relatively safe when used on a short-term basis (no more than 12 weeks).

How safe are proton pump inhibitors?

Proton pump inhibitors are safe. The experimental evidence suggests that proton pump inhibitors are safe to use, at least for a period of three years.

Do proton pump inhibitors have risks?

Proton Pump Inhibitor (PPI) Side Effects Kidney Disease, Injury and Failure. Studies dating back to the 1990s have associated PPIs with kidney problems. Clostridium Difficile (C. diff.) and Pneumonia Infections. Hip, Wrist and Spine Fractures. Esophageal and Gastric Cancer.