How do bacteria become resistant to clindamycin?
Most aerobic gram-negative bacteria, such as Pseudomonas spp and H. influenzae, are inherently resistant to clindamycin because of poor permeability of the cellular outer envelope to the drug.
Does clindamycin cause antibiotic resistance?
Although clindamycin resistance is concerning, there is a solution. When we use clindamycin alone topically, even in acne, it is more likely to cause bacterial resistance. However, when we combine clindamycin with benzoyl peroxide, the chance of resistance decreases significantly.
What is clindamycin inducible resistance?
Inducible resistance to clindamycin was defined as blunting of the clear circular area of no growth around the clindamycin disk on the side adjacent to the erythromycin disk and was designated D-test positive.
How do you fix antibiotic resistance?
To help fight antibiotic resistance and protect yourself against infection:
- Don’t take antibiotics unless you’re certain you need them. An estimated 30% of the millions of prescriptions written each year are not needed.
- Finish your pills.
- Get vaccinated.
- Stay safe in the hospital.
Does clindamycin work on STDs?
Clindamycin is in a class of medications called lincomycin antibiotics. It works by slowing or stopping the growth of bacteria. Vaginal clindamycin cannot be used to treat vaginal irritation caused by yeast infections or by sexually transmitted diseases such as chlamydia and trichomoniasis.
What is the molecular mechanism of TKI resistance?
And the molecular mechanism of TKI-resistance is that the ATP affinity of the oncogenic L858R mutant is increased by more than an order of magnitude, leading to resistance to Gefitinib. In a human bronchial epithelial cell line, overexpression of EGFR T790M confers a growth advantage over cells expressing wild type EGFR 29.
Are there any strains with inducible resistance to clindamycin?
Strains with inducible resistance to clindamycin are difficult to detect in the routine laboratory as they appear erythromycin-resistant and clindamycin sensitive in vitrowhen not placed adjacent to each other. In such cases, in vivotherapy with clindamycin may select constitutive erm mutants leading to clinical therapeutic failure.
How are TK inhibitors used to treat resistance?
Most of TK inhibitors (TKIs) are small molecular and hydrophobic compounds, thus they can rapidly reach their specific intracellular targets and inhibit the activation of the related TKs. Unfortunately, accompanied with patients who gain great benefit of TKIs therapy, increasing evidences of acquired resistance to these agents have been documented.
Is there a risk for MRSA resistance with clindamycin?
There is a risk for the appearance of resistance during clindamycin therapy of erythromycin-resistant MRSA infections because of the linked resistance mechanisms. Methods: We analyzed clindamycin-susceptible MRSA organisms from children (1987 to 2000) along with clinical data.