How do you dilute amiodarone infusion?

See section 4.2. Intravenous injection: 150-300 mg (corresponding to 3-6 ml Amiodarone) is diluted with 10-20 ml 5% w/v Glucose Intravenous Infusion.

Can you give amiodarone with normal saline?

Amiodarone is incompatible with saline and should be administered solely in 5% dextrose solution. Amiodarone diluted with 5% dextrose solution to a concentration of less than 0.6 mg/ml is unstable.

What should you check before administering amiodarone?

Before taking amiodarone, tell your doctor: If you have a history of lung, liver, heart or thyroid disease. Periodic blood work will need to be done to test your liver and thyroid function. You may also be asked to perform a breathing test to measure your pulmonary (lung) function.

How do you give amiodarone bolus?

Use of a 0.2 or 0.22 micron filter is recommended for intermittent and continuous infusions.

  1. Bolus doses: in 100 ml D5W over 10 min (maximum infusion rate 30 mg/min)
  2. Continuous infusion: in 500 ml D5W (in non PVC bag) over 24 hours.
  3. Cardiac Arrest: First dose: Give 300 mg (6 mL) IV direct UNDILUTED.

Can you IV push amiodarone?

May administer IV push for ventricular fibrillation or pulseless ventricular tachycardia. The same dosage may be given via the intraosseous route when IV access is not available. 5 mg/kg/dose IV; may repeat dose twice up to 15 mg/kg IV (Max single dose: 300 mg IV).

When should I stop amiodarone infusion?

Intravenously administered amiodarone causes heart block or bradycardia in 4.9 percent of patients and hypotension in 16 percent. 2 If these conditions occur, infusion of the drug should be discontinued, or the rate of infusion should be reduced.

What do you flush amiodarone with?

Amiodarone precipitates with Sodium Bicarbonate. Flushing with 10-20 ml of normal saline Page 2 SUBJECT : PATIENT CARE GUIDELINES AND STANDING ORDERS FOR BLS AND ALS UNITS REFERENCE NO. III-01 PUBLICATION : 1/11/21 IV-8 prior and after administration should avert this reaction.

What solution is amiodarone compatible with?

Amiodarone hydrochloride is stable when mixed with either 5% dextrose injection or 0.9% sodium chloride injection in polyvinyl chloride or polyolefin containers alone or with potassium chloride, lidocaine, procainamide, verapamil, or furosemide and stored for 24 hours at 24 degrees C.

What is the lowest dose of amiodarone?

Low-dose amiodarone (100-300 mg per day) is effective for a wide variety of ventricular and supraventricular arrhythmias, including in a rhythm control strategy for patients with atrial fibrillation, especially when structural heart disease is present.

How to administer Amiodarone IV?

Dosing. To prepare Amiodarone for an IV infusion, mix with D5W and give through an in-line filter. Alternatively, it is NOT necessary to dilute amiodarone for IV push administration and a filter is not necessary. When infusions exceed 2 hours, amiodarone can absorb into the plastic used for standard IV bags.

How to administer amiodarone bolus?

Administer via syringe driver at a rate of 100 mL/hour (over 30 minutes). Maintenance dose – 900 mg over 24 hours. Syringe preparation: Mix 150 mg (3 mL) of amiodarone with 47 mL of glucose 5% in a 50 mL syringe to achieve a final concentration of 3 mg/mL. Ensure all syringes are appropriately labelled.

Does IV amiodarone need to be diluted?

Alternatively, it is NOT necessary to dilute amiodarone for IV push administration and a filter is not necessary. When infusions exceed 2 hours, amiodarone can absorb into the plastic used for standard IV bags. This will change the medication concentration.