What does chemotherapy naive mean?

The patients all had to be chemotherapy-naïve, meaning that they had never received docetaxel or any cytotoxic chemotherapy for their prostate cancer.

Is abiraterone acetate chemotherapy?

by Drugs.com Zytiga (abiraterone acetate) is a type of hormone therapy that is used along with prednisone to treat men with prostate cancer that has spread to other parts of the body (metastasized). Despite being used to treat cancer, Zytiga is not a form of chemotherapy.

What is hormone naive metastatic prostate cancer?

Abstract. Hormone naïve advanced prostate cancer is subdivided into two disease states: biochemical recurrence and traditional M1 (metastatic) prostate cancer and characterized by no prior hormonal therapy or androgen deprivation therapy (ADT).

How effective is abiraterone after enzalutamide?

36% of the men having Enzalutamide second saw their PSA decline. But only 4% of men taking Abiraterone second had a decline in their PSA levels. The researchers predict that the better outcomes for group A are due to Enzalutamide working after Abiraterone, whereas Abiraterone does not seem to help when used second.

How long can you live taking abiraterone?

The median overall survival in the abiraterone group was 35.3 months (95% CI 31.2 to 35.3 months) and 30.1 months (95% CI 27.3 to 34.1 months) in the placebo group (HR 0.79, 95% CI 0.66 to 0.96, p=0.0151).

How long can you stay on abiraterone?

Life expectancy: The studies show that abiraterone acetate can prolong life. In the larger study, about 50 out of 100 men who had the standard treatment were still alive after 3 years, while after the same period of time 70 out of 100 men who had treatment with abiraterone acetate were still alive.

How effective is abiraterone acetate?

The pooled analysis reported abiraterone acetate showed significant efficacy in high-risk prostate cancer patients, including overall survival (OS) [HR 0.66, 95% confidence interval (CI), 0.61–0.73, P<0.001], the time to prostate-specific antigen (PSA) progression (HR 0.45, 95% CI, 0.34–0.59, P<0.001), progression-free …

How long can you survive Zytiga?

After a median follow-up of 51.8 months and a final analysis the overall survival has been confirmed to be significantly longer for patients receiving Zytiga/ADT/prednisone. Zytiga treated patients survived on average 53 months compared to 36.5 months for ADT alone.

How is abiraterone acetate used to treat prostate cancer?

Conclusions. Abiraterone acetate is a first-in-class inhibitor of cytochrome P-450c17, a critical enzyme in extragonadal and testicular androgen synthesis. 12-18 Abiraterone plus low-dose prednisone improves survival in patients with metastatic castration-resistant prostate cancer who have already received docetaxel,…

What are the end points of the abiraterone study?

The coprimary end points were radiographic progression-free survival and overall survival. The study was unblinded after a planned interim analysis that was performed after 43% of the expected deaths had occurred.

What’s the difference between abiraterone and enzalutamide?

Enzalutamide-treated patients who crossed over to abiraterone had a comparable risk of death versus abiraterone-treated patients who crossed over to enzalutamide (HR = 0.91; 95% CI, 0.74–1.13). These results were confirmed by sensitivity analysis, which considered prognostic variables.

Which is better for mCRPC patients enzalutamide or abiraterone?

Retrospective analysis of the VHA database indicated that chemotherapy-naive patients with mCRPC initiating therapy with enzalutamide had improved survival versus abiraterone. Despite disease progression on androgen deprivation therapy, castration-resistant tumors usually remain dependent on androgen receptor (AR) signaling.