What is the pKa value of arginine?

Amino Acid Abbreviation pKa (25 °C)
Arginine Arg 8.99
Asparagine Asn 8.72
Aspartic Acid Asp 9.90
Cysteine Cys 10.70

Why does arginine have high pKa?

Sometimes the amino acid side chain contains a basic group. Examples are histidine, lysine and arginine. The higher the pKa of the conjugate acid, the more tightly the proton is held, and so the more basic the nitrogen atom. Arginine is by far the most basic and histidine is the least basic.

Is Arginine an acidic amino acid?

At pH=7, two are negative charged: aspartic acid (Asp, D) and glutamic acid (Glu, E) (acidic side chains), and three are positive charged: lysine (Lys, K), arginine (Arg, R) and histidine (His, H) (basic side chains)….Charged side chains.

Amino acid pK of the side chain group
Lysine 10.5
Arginine 12.5
Histidine 6.0

What is the pKa of a carboxylic acid?

~ 5
The pKa of carboxylic acids typically ~ 5. They are significantly more acidic than water or alcohols.

Is a higher pKa more acidic?

Therefore, pKa was introduced as an index to express the acidity of weak acids, where pKa is defined as follows. In addition, the smaller the pKa value, the stronger the acid. For example, the pKa value of lactic acid is about 3.8, so that means lactic acid is a stronger acid than acetic acid.

Which amino acid has the highest pKa?

The amino acid which has the side chain with the highest pKa value is arginine (R).

Why arginine is a basic amino acid?

There are three amino acids that have basic side chains at neutral pH. These are arginine (Arg), lysine (Lys), and histidine (His). Their side chains contain nitrogen and resemble ammonia, which is a base. Their pKa’s are high enough that they tend to bind protons, gaining a positive charge in the process.

Which is the best name for PKA vaules?

Name pKa Hydrogen chloride -7 Acetone conjugate acid -7 Benzenesulfonic acid -6.5 Acetic acid conjugate acid -6

What is the molecular formula of pivalic acid?

Pivalic acid is a carboxylic acid with a molecular formula of (CH3)3CCO2H. This colourless, odiferous organic compound is solid at room temperature.

Which is the best way to protect pivalic acid?

Common protection methods include treatment of alcohol with pivaloyl chloride (PvCl) in presence of pyridine. Alternatively, the esters can be prepared using pivaloic anhydride in the presence of scandium triflate (Sc (OTf) 3) or vanadyl triflate (VO (OTf) 2). Common deprotection methods involve hydrolysis with a base or other nucleophiles.

What are the values of pKa1 and Pi?

Amino acid pKa1 pKa2 pI Glutamine 2.17 9.13 5.65 Serine 2.21 9.15 5.68 Threonine 2.09 9.10 5.60 Tyrosine 2.20 9.11 5.66